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Micellar electrokinetic capillary chromatography as a method for the determination of n ‐octanol/water partition coefficients of pesticides
Author(s) -
Dinelli Giovani,
Mallegni Roberto,
Vicari Alberto
Publication year - 1997
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150180207
Subject(s) - micellar electrokinetic chromatography , chromatography , chemistry , partition coefficient , electrokinetic phenomena , capillary action , pesticide , capillary electrophoresis , materials science , agronomy , biology , composite material
Micellar electrokinetic capillary chromatography (MEKC) was used to determine the n ‐octanol/water partition coefficient ( K ow ) of nonionic and ionic organic chemicals, mainly herbicides. Three electrolyte buffer systems with different organic modifiers were tested to evaluate their effect on the linear relationship between log K ow and log ḱ. The effect of the pH value of injected samples on linear log K ow /log ḱ relationship of ionic chemicals was also evaluated. Since a good correlation was found between log K ow values and the logarithms of the capacity factor (ḱ) of each tested organic solvent, other parameters were considered to evaluate the efficacy of the method, such as the rate of electroosmotic flow, the efficiency and reproducibility of the separation, and the separation number ( n ). The method was found to be applicable over a range of log K ow values from 0.72 to 5.1 and demonstrated a good predictive capability, giving similar results to direct experimental measures, at least within classes of compounds with similar physico‐chemical properties.