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Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis
Author(s) -
Kilár Ferenc
Publication year - 1996
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150171224
Subject(s) - capillary electrophoresis , enantiomer , chemistry , chromatography , stereoselectivity , pindolol , atenolol , transferrin , diastereomer , promethazine , propranolol , labetalol , electrophoresis , pharmacology , stereochemistry , biochemistry , receptor , medicine , blood pressure , radiology , catalysis
Stereoselective interaction of drugs with human serum transferrin in capillary zone electrophoresis is described. The substances passed a pseudo‐stationary protein zone applied in a coated capillary and the possible chiral separation of the optical isomers was followed. Drugs with different structures were screened and the enantiomers of bupivacaine, propranolol and promethazine as well as the diastereomers of labetalol were resolved. Racemic mixtures of atenolol and pindolol enantiomers could not be resolved under these conditions.