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Dextrin sulfopropyl ether: A novel anionic chiral buffer additive for enantiomer separation by electrokinetic chromatography
Author(s) -
Jung Martin,
Börnsen K. Olaf,
Francotte Eric
Publication year - 1996
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150170122
Subject(s) - dextrin , enantiomer , chemistry , chromatography , cationic polymerization , capillary electrophoresis , ether , micellar electrokinetic chromatography , organic chemistry , starch
Dextrin 10 sulfopropyl ether (DSPE) was prepared and characterized matrix‐assisted laser‐desorption ionization‐mass spectrometry (MALDI‐M) using a recently developed matrix. The anionic compound was used as a novel chiral buffer additive for enantiomer separation by capillary electrophoresis, thereby changing into the elektrokinetic chromatography (EKC) mode. DSPE was systematically evaluated as a chiral selector and was compared to the respective nonderivatized maltodextrin. DSPE showed an increased separation power for cationic racemic solutes. Although not quite as versatile and powerful as cyclodextrins, the inexpensive dextrin 10 and its derivative DSPE showed remarkable enantioselectivity in some cases.