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An informativity index for multilocus DNA fingerprints
Author(s) -
Krawczak Michael,
Lubjuhn Thomas
Publication year - 1995
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150160105
Subject(s) - index (typography) , dna profiling , fingerprint (computing) , dna , computational biology , biology , chemistry , genetics , computer science , artificial intelligence , world wide web
An informativity index for multilocus DNA fingerprints, r , was developed. It is based upon the Shannon information that a paternal DNA fingerprint conveys about the offspring phenotype pattern. Both simulation and empirical data reveal that the index r is strongly correlated with the mean log likelihood ratio (paternity vs . nonpaternity) expected in trio cases of true paternity. Since r can be estimated from DNA fingerprints of unrelated individuals in advance, it will provide an easy means to assess the potential utility of a given probe/enzyme combination in kinship testing.