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Analysis of the inter‐alpha‐trypsin inhibitor polymorphism in West Africa: Description of a new allele, ITI*7
Author(s) -
Caeiro José Luis B.,
Liste Isabel,
Vogt Ulrike,
Ribeiro Joaquim C. Teixeira
Publication year - 1994
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.11501501179
Subject(s) - allele , immunofixation , isoelectric focusing , genetics , allele frequency , biology , genotype , population , polymorphism (computer science) , microbiology and biotechnology , gene , medicine , biochemistry , environmental health , monoclonal , antibody , monoclonal antibody , enzyme
Inter‐α‐trypsin inhibitor (ITI) phenotypes were classified in the West African population of Cabo Verde by polyacrylamide gel isoelectric focusing, followed by immunofixation and silver staining. Gene frequencìes of the alleles ITI*1, ITI*2, ITI*3 and ITI*4 were calculated to be 0.532, 0.153, 0.307 and 0.002, respectively. A new rare allele, ITI*7, was found, providing evidence for further genetic variability of the ITI protein. The ITI*7 allele frequency has been determined to 0.006. The assumption that allele ITI*3 may be used to characterize populations of African origin is supported by our data.