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Micellar electrokinetic capillary chromatography analysis of water‐soluble vitamins and multi‐vitamin integrators
Author(s) -
Dinelli Giovanni,
Bonetti Alessandra
Publication year - 1994
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.11501501173
Subject(s) - chromatography , micellar electrokinetic chromatography , chemistry , extraction (chemistry) , reproducibility , electrokinetic phenomena , resolution (logic) , capillary action , capillary electrophoresis , analytical chemistry (journal) , materials science , artificial intelligence , computer science , composite material
Micellar electrokinetic capillary chromatography (MECC) was applied to the determination of water‐soluble vitamins (WSV) in pharmaceutical preparations. The analytical procedure employed in the WSV separation by MECC showed a satisfactory average column efficiency (195000 N ) and resolution (more than 100 theoretical peaks separable). The mean reproducibility in the retention time of consecutive and day‐to‐day runs was 1.1% and 5.1%, respectively. Analyses were performed after extraction of active ingredients by solid phase extraction. Recoveries (92–103%) and relative variation coefficients (less than 5%) confirmed the potential of MECC in the field of pharmaceutical analysis.