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Inter‐α‐trypsin inhibitor polymorphism in African blacks
Author(s) -
Vogt Ulrike,
Gürtler Lutz,
Cleve Hartwig
Publication year - 1992
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150130168
Subject(s) - allele , allele frequency , genetics , polymorphism (computer science) , biology , population , gene , microbiology and biotechnology , medicine , environmental health
The inter‐α‐trypsin inhibitor (ITI) polymorphism was analyzed in an African Negroid population using polyacrylamide gel isoelectic focusing and subsequent immunoblotting. Gene frequencies of ITI*1, ITI*2, ITI*3 and ITI*4 were calculated to be 0.564, 0.083, 0.337 and 0.004, respectively. One unknown rare allele, ITI*6 determines further phenotypes in combination with the alleles ITI*1 and ITI*3 Gene frequency of ITI*6 was calculated to be 0.012. The common alleles are represented by ITI*1 and ITI*3. The allele distribution is therefore different from European and Asian populations.