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Two‐dimensional gel electrophoresis analysis of Syrian hamster embryo cells: Morphological transformation is not cell type specific
Author(s) -
Isfort Robert J.,
Kerckaert Gary,
Leigh Anderson N.,
LeBœuf Robert A.
Publication year - 1992
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.11501301187
Subject(s) - hamster , phenotype , cell , biology , embryo , cell type , transformation (genetics) , mesenchymal stem cell , microbiology and biotechnology , population , gel electrophoresis , cell culture , chemistry , genetics , gene , demography , sociology
Studies were conducted to investigate the protein phenotype of normal and morphologically transformed Syrian hamster embryo (SHE) cells. Based upon two‐dimensional gel protein phenotype analysis, we conclude that (i) SHE cells are a mixture of multiple cell types including mesenchymal and epithelial cells and (ii) several cell types present in the SHE cell population can be morphologically transformed by a variety of genotoxic and non‐genotoxic carcinogens.