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Enantiomers resolution in capillary zone electrophoresis by using cyclodextrins
Author(s) -
Schutzner Wolfgang,
Fanali Salvatore
Publication year - 1992
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.11501301146
Subject(s) - enantiomer , capillary electrophoresis , cyclodextrin , chemistry , resolution (logic) , chromatography , analyte , electrolyte , stereochemistry , electrode , artificial intelligence , computer science
Cyclodextrins added to the background electrolyte are shown to be useful for the resolution of racemic compounds in their enantiomers. Several parameters have to be controlled in order to achieve resolution, e.g. , cyclodextrin type, concentration, analyte shape, as well as column temperature. The resolution of nor‐epinephrine, epinephrine and isoproterenol in their enantiomers decreased by increasing the column temperature. Octopamine and ketamine have been resolved by supporting the background electrolyte with 2, 6‐di‐O‐methyl‐β‐cyclodextrin. In spite of the stronger inclusion‐complex of ketamine than octopamine with the modified cyclodextrin its resolution was not satisfactory.