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A genetic factor model for the statistical analysis of multilocus DNA fingerprints
Author(s) -
Krawczak Michael,
Bockel Barbara
Publication year - 1992
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150130104
Subject(s) - dna profiling , linkage (software) , biology , genetics , statistical model , dna , computational biology , evolutionary biology , statistics , mathematics , gene
A novel concept is described for the statistical analysis of multilocus DNA fingerprints. Utilizing this method, it is shown by simulation that the application of multilocus DNA fingerprints to paternity testing is robust against deviations from idealistic assumptions made about underlying models and parameters. Partial homozygosity, allelism and linkage at the DNA loci involved, as well as variations in estimates of band‐sharing probabilities were studied for effects on the resulting paternity probabilities. None of the above‐mentioned phenomena appear to change these values to an extent relevant for decision making in paternity cases.