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The grammatical rule for all DNA: Junk and coding sequences
Author(s) -
Ohno Susumu,
Yomo Tetsuya
Publication year - 1991
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150120203
Subject(s) - dna , genome , encode , noncoding dna , genetics , palindrome , coding (social sciences) , dna sequencing , computational biology , biology , mathematics , gene , statistics
Selfish DNA, coding sequences, and junk DNA in the genome are no stranger to each other; rather, they represent three phases in the life cycle of DNA. Accordingly, they all obey the same grammatical rule of TG/CA/CT excess and CG/TA deficiency. On the one hand, it is this very rule which keeps isoelectric points of most proteins near the neutral range. On the other hand, this rule creates numerous palindromes, thus maintaining symmetry between complementary strands. Many of these palindromes encode identical oligopeptides on both strands.