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Enantiomer resolution by using capillary zone electrophoresis: Resolution of racemic tryptophan and determination of the enantiomer composition of commercial pharmaceutical epinephrine
Author(s) -
Fanali Salvatore,
Boček Petr
Publication year - 1990
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150110913
Subject(s) - enantiomer , capillary electrophoresis , chromatography , chemistry , resolution (logic) , cyclodextrin , tryptophan , epinephrine , electrolyte , electrophoresis , stereochemistry , biochemistry , medicine , amino acid , electrode , artificial intelligence , computer science
The enantiomers of D‐ and L‐tryptophan were separated by capillary electrophoresis, using α‐cyclodextrin as a chiral active component in the background electrolyte. The separation of (‐) and (+) epinephrine was achieved by supplementing the background electrolyte with Heptakis (2,6‐di‐ O ‐methyl‐β‐cyclodextrin). As a practical application of the method, the quantitative analysis of (‐)and(+)enantiomers in commercial pharmaceutical solutions of adrenaline is shown.