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Interpretation of DNA profiles using a computerised database
Author(s) -
Gill Peter,
Werrett David J.
Publication year - 1990
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150110516
Subject(s) - hypervariable region , analyser , computer science , interpretation (philosophy) , computational biology , locus (genetics) , dna , data mining , biological system , pattern recognition (psychology) , artificial intelligence , biology , genetics , chemistry , chromatography , gene , programming language
An image analyser has been utilised to store data derived from autoradiography of hypervariable loci (both multi and single locus). By examination of the electrophoretic system, it is possible to assign standard deviations to bands and then to determine whether the bands ‘match’ each other. The problems associated with the practical applications of such a system are discussed. Improvements are suggested such as the adoption of internal markers.