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Two‐dimensional electrophoresis of heart muscle proteins in human cardiomyopathies
Author(s) -
Kovalyov Leonid I.,
Naumov Vladimir G.,
Pulyayeva Helena V.,
Samko Anatoli M.,
Tsvetkova Mari.,
Shishkin Sergei S.,
Mukharlyamov Nurmukhmmed M.
Publication year - 1990
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150110412
Subject(s) - autopsy , cardiomyopathy , dilated cardiomyopathy , myocarditis , myosin , medicine , human heart , cardiology , pathology , heart failure , biology , biochemistry
Human heart muscle proteins have been analyzed by two‐dimensional electrophoresis. Twenty five autopsy heart muscle samples obtained from individuals who had died in accidents and who had no signs of cardiovascular pathology have been compared with biopsy and autopsy myocardium samples of patients with: dilated cardiomyopathy (5 cases), hypertrophical cardiomyopathy (2 cases) and myocarditis (2 cases). In dilated cardiomyopathy in 3 out of 5 cases an additional protein spot was found in the myocardial myosin light chain 1 area.