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Polymorphism of aldehyde dehydrogenase and its application to alcoholism
Author(s) -
Harada Shoji
Publication year - 1989
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150100820
Subject(s) - aldehyde dehydrogenase , aldh2 , isozyme , mongoloid , alcohol dehydrogenase , polymorphism (computer science) , population , allele , genetics , biology , biochemistry , alcohol , enzyme , medicine , gene , environmental health
Aldehyde dehydrogenase (ALDH) consists of four different isozymes (I, II, III, IV). Among these, ALDH I shows genetic polymorphism (normal and deficient) in a population of Mongoloid origin. The significantly lower frequency of ALDH I deficiency was found in alcoholic patients compared with healthy controls. ALDH I deficiency is one of the important genetic factors in regulating alcohol consumption and plays a protective role against alcoholism. Population genetic studies on ALDH I deficiency in different ethnic groups indicate that ALDH deficiency was found only in Mongoloid population groups.