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Elevated plasma levels of haptoglobin in duchenne muscular dystrophy: Electrophoretic variants in patients with a severe form of the disease
Author(s) -
John Huw A.,
Purdom Ian F.
Publication year - 1989
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150100707
Subject(s) - haptoglobin , duchenne muscular dystrophy , densitometry , blood proteins , muscular dystrophy , electrophoresis , medicine , chemistry , endocrinology , biochemistry
Analysis of plasma proteins of Duchenne, muscular dystrophy (DMD) patients and normal age‐matched boys using two dimensional gel electrophoresis and densitometry indicated a three‐fold increase in the average haptoglobin level in DMD plasma. Two electrophoretic variants of haptoglobin in which the α 2 chain had more basic or more acidic spots were found in DMD patients with a rapidly progressing form of the disease. The basic variant was present in relatively low amount. Possible reasons for the elevated haptoglobin levels are discussed.