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Monte Carlo simulation of DNA electrophoresis
Author(s) -
Batoulis Jannis,
Pistoor Norbert,
Kremer Kurt,
Frisch Harry L.
Publication year - 1989
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150100522
Subject(s) - monte carlo method , statistical physics , electrophoresis , dna , computational biology , computer science , chromatography , chemistry , physics , biology , mathematics , statistics , biochemistry
This paper describes an attempt to study the electrophoresis mobility of a DNA molecule in a gel by means of a Monte Carlo simulation. We find that the electrophoresis mobility μ can be well described by the empirical equation μ = κ 1 / N + κ 2 E 2 with N being the number of monomers of the model chain and E being the applied field. For small E the data can merge into the linear response result μ = κ 1 / N . The paper also discusses necessary extensions of the present approach.