Monte Carlo simulation of DNA electrophoresis | Zendy

Batoulis Jannis | Zendy; Pistoor Norbert | Zendy; Kremer Kurt | Zendy; Frisch Harry L. | Zendy

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Monte Carlo simulation of DNA electrophoresis

Author(s) -

Batoulis Jannis,

Pistoor Norbert,

Kremer Kurt,

Frisch Harry L.

Publication year - 1989

Publication title -

electrophoresis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 158

eISSN - 1522-2683

pISSN - 0173-0835

DOI - 10.1002/elps.1150100522

Subject(s) - monte carlo method , statistical physics , electrophoresis , dna , computational biology , computer science , chromatography , chemistry , physics , biology , mathematics , statistics , biochemistry

This paper describes an attempt to study the electrophoresis mobility of a DNA molecule in a gel by means of a Monte Carlo simulation. We find that the electrophoresis mobility μ can be well described by the empirical equation μ = κ 1 / N + κ 2 E 2 with N being the number of monomers of the model chain and E being the applied field. For small E the data can merge into the linear response result μ = κ 1 / N . The paper also discusses necessary extensions of the present approach.

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