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An evaluation of two‐dimensional electrophoresis for detection of human serum proteins in acute myocardial infarction
Author(s) -
Marshall Thomas,
Williams John,
Williams Katherine M.
Publication year - 1988
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150091009
Subject(s) - myocardial infarction , acute phase protein , electrophoresis , gel electrophoresis of proteins , serum protein electrophoresis , blood proteins , medicine , gel electrophoresis , cardiology , chemistry , chromatography , immunology , polyacrylamide gel electrophoresis , biochemistry , enzyme , inflammation , antibody , monoclonal , monoclonal antibody
High resolution two‐dimensional electrophoresis indicates that serum proteins previously only detected in patients with acute myocardial infarction (AMI) (Gomo et al. , Electrophoresis 1983, 4 , 298–302) are also present in the serum protein patterns of other patients (AMI negative or demonstrating acute phase response) and are faintly detected even in controls. Thus, these proteins are not specific to AMI and are probably acute phase reactants. However, they do demonstrate a characteristic time course response in sequential samples from AMI patients.