Premium
The group specific component/vitamin D binding protein (GC/DBP) system in the analysis of disputed paternities
Author(s) -
Constans Jacques,
Cleve Hartwig
Publication year - 1988
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150090809
Subject(s) - vitamin d binding protein , component (thermodynamics) , group (periodic table) , chemistry , vitamin , chromatography , biochemistry , organic chemistry , physics , thermodynamics
The group‐specific component (GC) was discovered in 1959, and in the same year a vitamin D binding protein (DBP) in human plasma was found; however, their identity was established as late as 1975. In the GC/DBP system three common alleles, GC*1F, GC*1S, and GC*2, determine six GC phenotypes: 1F, 1S, 2, 1F‐1S, 2‐1F and 2‐1S, these common alleles having been found in all human populations studied. In addition, more than 120 GC variants have been discovered, with varying frequencies in different populations. The distribution of the common GC phenotypes and the presence of rare GC variant phenotypes render the GC/DBP system useful for the analysis of disputed paternities.