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Genetic polymorphism of human serum transferrin in the swiss population: Evidence for three “new” transferrin‐variants
Author(s) -
Scherz Rudolf,
Reber Beatrice,
Pflugshaupt Rolf,
Bütler René
Publication year - 1985
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150061112
Subject(s) - transferrin , allele , mendelian inheritance , genetics , phenotype , biology , polymorphism (computer science) , allele frequency , hardy–weinberg principle , population , gene , medicine , biochemistry , environmental health
Genetic polymorphism of transferrin (Tf) was studied in 473 healthy Swiss blood donors and 236 nonrelated individuals engaged in cases of disputed paternity. Gene frequencies were: Tf C1 = 0.7727, Tf C2 = 0.1634, Tf C3 = 0.0573. Several rare alleles were observed, the frequency of the total of which was 0.0066. Three obviously new Tf alleles were detected. The phenotype distribution was in agreement with the Hardy Weinberg equilibrium. Among 113 mother/child pairs no phenotypes contradictory to the mendelian law were observed. The transferrin system represents a useful parameter in routine paternity testing. Its average chance of exclusion (without rare alleles) is 18.19%.