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Distribution of plasminogen allotypes in eight populations of the Western Hemisphere
Author(s) -
Dykes Dale,
Nelson Mary,
Polesky Herbert
Publication year - 1983
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150040609
Subject(s) - isoelectric focusing , biology , genetics , population , microbiology and biotechnology , demography , biochemistry , sociology , enzyme
Phenotyping for plasminogen (PLG) variants on 0.5 mm agarose isoelectric focusing gels enabled us to identify six different allotypes among the eight populations studied. PLG *1 and PLG *2 were seen at polymorphic frequencies in all the populations studied except Eskimos which had a gene frequency of 0.993 for PLG *1. The variants PLG *3, PLG *B, were seen at low frequencies in some of the populations, whereas PLG *M was only identified in the local White population. A new variant named PLG *D, which we consider to be a marker of black populations, was identified in local Blacks and Black Caribs at frequencies of 0.037 and 0.058, respectively.