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Analysis of the genetic variants of the human Gc system (VDBP) by isoelectric focusing in immobilized pH gradients
Author(s) -
Cleve Hartwig,
Patutschnick Walburgis,
Postel Wilhelm,
Weser Johann,
Görg Angelika
Publication year - 1982
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150030609
Subject(s) - isoelectric focusing , isoelectric point , chromatography , chemistry , genetic variants , resolution (logic) , immobilized ph gradient , biochemistry , enzyme , gene , genotype , artificial intelligence , computer science
The genetic variability of the human group‐specific component (Gc) system has been examined by isoelectric focusing with immobilized pH gradients. The phenotypes of the six common Gc types and of 15 rare genetic Gc variants are described and presented. High resolution of the Gc components is accomplished. The classification can be made without specific immune reaction. Isoelectric focusing with immobilized pH gradients represents a powerful tool for analyzing genetic variability.