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Transferrin (Tf) subtypes in US Amerindians, Whites and Blacks using thin‐layer agarose gels: Report on a new variant Tf C8
Author(s) -
Dykes Dale D.,
DeFurio Cathryn M.,
Polesky Herbert F.
Publication year - 1982
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.1150030309
Subject(s) - agarose , isoelectric focusing , subtyping , population , transferrin , microbiology and biotechnology , biology , locus (genetics) , chemistry , genetics , chromatography , gene , biochemistry , medicine , enzyme , environmental health , computer science , programming language
Using 0.5 mm agarose gels for Tf subtyping by isoelectric focusing we were able to identify ten variants at the Tf locus in US Amerindians, Whites and Blacks. The variant Tf C4 was found only in the Amerindian populations. This population specific variant had gene frequncies ranging from 0.079 in the Walapi to 0.179 in the Apache. The Black sample studied had a lower incidence of Tf C3 than in whites and was the only population with the marker Tf D1 . Thin agarose gels provided good separation of Tf C3 from Tf C1 . Thin agarose gels provided good separation of Tf C3 from Tf C1 enabling us to demonstrate a new variant, Tf C8 , migrating between Tf C1 and Tf C3 .