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A Highly Sensitive Electrochemiluminescence Spermine Biosensor Based on Au−Ag Bimetallic Nanoclusters
Author(s) -
Guo Yongliang,
Tian Lili,
Wu Jiangming,
Wu Yang,
Liu Yongmei,
Du Jie,
Lu Xiaoquan
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202100169
Subject(s) - electrochemiluminescence , nanoclusters , bimetallic strip , detection limit , bioanalysis , biosensor , polyaniline , materials science , triethylamine , nanotechnology , analytical chemistry (journal) , combinatorial chemistry , chemistry , chromatography , metal , organic chemistry , polymer , metallurgy , composite material , polymerization
In this study, we found that spermine (SPM) could enhance electrochemiluminescence (ECL) intensity of Au−Ag bimetallic nanoclusters (Au−Ag BNCs) with triethylamine (TEA) as a co‐reactant. An ECL sensor was fabricated to detect SPM, which contained Au−Ag BNCs as ECL emitters and conductive hydrogel containing polyaniline‐amino trimethylene phosphonic acid (PANI‐ATMP) as an immobilizing matrix. The increased ECL intensity of SPM was linear with the logarithm of concentrations of SPM in the range of 1 pM to 10 μM with high selectivity, excellent stability, and the limit of detection is 0.11 pM (S/N=3). This sensor realized the detection of SPM in urine samples, which was fast and economic, possessing potential applications for SPM detection in clinical and bioanalysis.