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Electrochemical Biosensor Design with Multi‐walled Carbon Nanotube to Display DNA‐Schiff Base Interaction
Author(s) -
Munir Azeema,
BozalPalabiyik Burcin,
Eren Gokcen,
Shah Afzal,
Ali Saqib,
Uddin Noor,
Uslu Bengi
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202100156
Subject(s) - biosensor , differential pulse voltammetry , schiff base , carbon nanotube , combinatorial chemistry , dna , chemistry , electrochemistry , cyclic voltammetry , nanotechnology , photochemistry , materials science , polymer chemistry , biochemistry , electrode
This paper demonstrates a Schiff base i. e. 5‐(diethylamino)‐2‐((2,6‐diethylphenylimino)methyl)phenol (5‐DDMP) that was sensed by DNA biosensor. dsDNA was immobilized onto GCE modified with functionalized multi‐walled carbon nanotubes to prepare a biosensor. The efficiency of dsDNA biosensor was determined and binding of 5‐DDMP with dsDNA was searched by UV‐vis spectrophotometry and differential pulse voltammetry. Molecular docking simulations between 5‐DDMP and dsDNA were explored and as a result, a hydrogen bond and a π‐π contact were observed between 5‐DDMP and deoxyguanosine base (dG22) of the strand B, deoxyadenosine base (dA5) of the strand A, respectively. These studies could be useful for new anticancer drug design and development.