Isoniazid‐sensing Behavior of a Hybrid Silsesquioxane and Cobalt Pentacyanonitrosylferrate‐based Nanocomposite

A novel silsesquioxane and cobalt nitroprusside compound was prepared from octa(aminopropyl)silsesquioxane, resulting in a nanocomposite (ACCoN), which was then characterized by different spectroscopic techniques. The cyclic voltammograms of the ACCoN‐modified graphite paste electrode indicated a redox pair with a formal potential (E θ′ )=0.38 V, assigned to the Co (II) Fe (II) (CN) 5 NO/Co (II) Fe (III) (CN) 5 NO redox couple. The ACCoN‐modified graphite paste electrode was sensitive to isoniazid concentrations, presenting a linear response at a concentration range from 6.0×10 −7 to 1.0×10 −5  mol L −1 , with limit of detection and amperometric sensitivity of 5.53×10 −7  mol L −1 and 0.17 A/mol L −1 , respectively.