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Determination of Tedizolid Phosphate Using Graphene Nanocomposite Based Solid Contact Ion Selective Electrode; Green Profile Assessment by Eco‐scale and GAPI Approach
Author(s) -
Moaaz Eman M.,
Mahmoud Amr M.,
Fayed Ahmed S.,
Rezk Mamdouh R.,
AbdelMoety Ezzat M.
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202100067
Subject(s) - graphene , electrode , materials science , nanocomposite , reproducibility , phosphate , chemical engineering , nanotechnology , chemistry , chromatography , organic chemistry , engineering
Antibiotics determination plays a major role in minimizing antimicrobial resistance starting from quality control of pharmaceutical formulations to therapeutic drug monitoring. Green modified glassy carbon electrode has been developed for determination of tedizolid phosphate; new antibiotic prodrug; in presence of its active metabolite. The graphene transducer interlayer, dispersed with PVC, improved the electrode stability and standard potential reproducibility. Graphene hydrophobicity prevented the water layer formation between the sensing layers that decreased the potential drift down to 267 μV h −1 . Electrochemical impedance showed a low resistance value for graphene containing sensor due to its high electron transfer ability.