A New Voltammetric Approach for Electrochemical Determination of Lamotrigine in Pharmaceutical Samples | Zendy

Ciucu Anton A. | Zendy; Buleandră Mihaela | Zendy; Ciurea Tatiana | Zendy; Stoica Vlad N. | Zendy; Ştefanescu Cristian D. | Zendy; Ciobanu Adela | Zendy

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A New Voltammetric Approach for Electrochemical Determination of Lamotrigine in Pharmaceutical Samples

Author(s) -

Ciucu Anton A.,

Buleandră Mihaela,

Ciurea Tatiana,

Stoica Vlad N.,

Ştefanescu Cristian D.,

Ciobanu Adela

Publication year - 2021

Publication title -

electroanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 128

eISSN - 1521-4109

pISSN - 1040-0397

DOI - 10.1002/elan.202100037

Subject(s) - linear sweep voltammetry , detection limit , voltammetry , lamotrigine , linear range , electrochemistry , pharmaceutical formulation , cyclic voltammetry , electrode , linear relationship , analytical chemistry (journal) , chemistry , materials science , chromatography , mathematics , medicine , psychiatry , epilepsy , statistics

A new linear sweep voltammetric method for quantitative lamotrigine (LMT) determination based on an electrochemically pre‐treated pencil graphite electrode (PGE*) is presented. Response characteristics of the PGE* toward the mentioned compound were investigated by cyclic voltammetry and linear sweep voltammetry. The quantitative determination of LMT revealed a wide linear range of 2.5 ⋅ 10 −5 –1.0 ⋅ 10 −3 M with a detection limit of 1.94 ⋅ 10 −5 M. The method was used successfully for LMT determination in a pharmaceutical formulation.

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