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A New Voltammetric Approach for Electrochemical Determination of Lamotrigine in Pharmaceutical Samples
Author(s) -
Ciucu Anton A.,
Buleandră Mihaela,
Ciurea Tatiana,
Stoica Vlad N.,
Ştefanescu Cristian D.,
Ciobanu Adela
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202100037
Subject(s) - linear sweep voltammetry , detection limit , voltammetry , lamotrigine , linear range , electrochemistry , pharmaceutical formulation , cyclic voltammetry , electrode , linear relationship , analytical chemistry (journal) , chemistry , materials science , chromatography , mathematics , medicine , psychiatry , epilepsy , statistics
A new linear sweep voltammetric method for quantitative lamotrigine (LMT) determination based on an electrochemically pre‐treated pencil graphite electrode (PGE*) is presented. Response characteristics of the PGE* toward the mentioned compound were investigated by cyclic voltammetry and linear sweep voltammetry. The quantitative determination of LMT revealed a wide linear range of 2.5 ⋅ 10 −5 –1.0 ⋅ 10 −3 M with a detection limit of 1.94 ⋅ 10 −5 M. The method was used successfully for LMT determination in a pharmaceutical formulation.