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Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis
Author(s) -
Nascimento Botelho Chirlene,
Pavão e Pavão Daniele,
Santos Damos Flávio,
Cássia Silva Luz Rita
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202100023
Subject(s) - detection limit , isoniazid , amperometry , cadmium telluride photovoltaics , dielectric spectroscopy , ruthenium , titanium dioxide , electrochemical gas sensor , materials science , chloride , electrochemistry , chemistry , nuclear chemistry , inorganic chemistry , nanotechnology , tuberculosis , chromatography , organic chemistry , catalysis , electrode , medicine , metallurgy , pathology
Abstract The present work describes the development of a photoelectrochemical sensor based on titanium dioxide, cadmium telluride quantum dots and the tris (2,2′‐bipyridyl) ruthenium(II) chloride complex for detection of Isoniazid (INH). The Ru(bpy) 3 2+ /CdTe‐QDs/TiO 2 /FTO photoelectrochemical platform was characterized by scanning electrochemical microscopy, electrochemical impedance spectroscopy and amperometry. The photoelectrochemical sensor presented two linear ranges for INH concentrations ranging from 0.5 to 150 μmol L −1 and 150 to 1270 μmol L −1 , with a theoretical detection limit of 0.02 μmol L −1 . The sensor was successfully applied for the determination of INH in drugs samples used in the treatment of tuberculosis.