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Molecularly Imprinted Poly‐o‐phenylenediamine Electrochemical Sensor for Entacapone
Author(s) -
Radi AbdElgawad,
Ragaa AbdEllatief Maha
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202100022
Subject(s) - differential pulse voltammetry , entacapone , detection limit , electrochemical gas sensor , cyclic voltammetry , molecularly imprinted polymer , dielectric spectroscopy , electrochemistry , chemistry , amperometry , glassy carbon , materials science , nuclear chemistry , selectivity , electrode , chromatography , organic chemistry , medicine , levodopa , disease , pathology , parkinson's disease , catalysis
We have developed a molecularly imprinted polymer (MIP) electrochemical sensor for entacapone (ETC) based on an electropolymerised polyphenylenediamine (Po‐PD) on a glassy carbon electrode (GCE) surface. The direct electropolymerisation of the o‐phenylenediamine monomer (o‐PD) was carried out with ETC as a template. The steps of electropolymerization process, template removal and binding of the analyte were tested by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) using [Fe(CN) 6 ] 3− /[Fe(CN) 6 ] 4 − as a redox probe. The operation of the sensor has been investigated by differential pulse voltammetry (DPV). Under optimal experimental conditions, the response of the DPV was linearly proportional to the ETC concentration between 1.0×10 −7 and 5.0×10 −6 M ETC with a limit of detection (LOD) of 5.0×10 −8 M. The developed sensor had excellent selectivity without detectable cross‐reactivity for levodopa and carbidopa. The MIP sensor was successfully used to detect ETC in spiked human serum samples.