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A Novel Molecule: 1‐(2,6 Dichlorobenzyl)‐4‐(2‐(2‐4‐hydroxybenzylidene)hydrazinyl)pyridinium Chloride and its Interaction with DNA
Author(s) -
Karasakal Ayça,
Parlar Sülünay,
Alptüzün Vildan,
Cetin Arif E.,
Topkaya Seda Nur
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060597
Subject(s) - pyridinium , differential pulse voltammetry , chemistry , molecule , cyclic voltammetry , dna , pyridine , guanine , dielectric spectroscopy , electrochemistry , chloride , combinatorial chemistry , photochemistry , medicinal chemistry , organic chemistry , biochemistry , electrode , nucleotide , gene
Herein, a novel pyridine derivative, 1‐(2,6 dichlorobenzyl)‐4‐(2‐(2‐4‐hydroxybenzylidene)hydrazinyl)‐pyridinium chloride (DHPC), was synthesized as a candidate drug molecule. Interaction of DHPC with DNA was used to explore its effect on DNA via Differential Pulse Voltammetry, Cyclic Voltammetry, and Electrochemical Impedance Spectroscopy. We demonstrated that oxidation signal of guanine bases of DNA decreased significantly while that of DHPC increased after its interaction with one another. Our candidate drug molecule exhibits LOD and LOQ, e.g., 1.5 μg/mL and 4.9 μg/mL, respectively. Toxicity effect value for DHPC (S%) was calculated as %31, demonstrating the candidate drug molecule's toxic effect on DNA.