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Hemin‐phytic Acid Functionalized Porous Conducting Polymer Hydrogel With Good Biocompatibility for Electrochemical Detection of H 2 O 2 Released From Living Cells
Author(s) -
Shang Xin,
He Shaoying,
Xu Zhiai,
Lu Wei,
Zhang Wen
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060499
Subject(s) - biocompatibility , hemin , polyaniline , electrochemistry , detection limit , electrode , materials science , selectivity , conductive polymer , conductivity , nuclear chemistry , chemical engineering , catalysis , chemistry , polymer , chromatography , organic chemistry , enzyme , heme , engineering , metallurgy , composite material , polymerization
A novel hemin/phytic acid doped polyaniline (PA‐PANI) hydrogel composite was prepared through a simple chemical and self‐assembly method, which was modified onto electrode for electrochemical detection of H 2 O 2 released from living cells. It showed good analytical performance with high sensitivity, selectivity and a rapid response for the analysis of H 2 O 2 in the range of 2 to 102 μM, with the detection limit of 1.2 μM. The favorable results mainly originated from both the high conductivity of PA‐PANI hydrogel and its network structure preventing hemin from self‐dimerization to provide active catalytic species. Furthermore, PA‐PANI with good biocompatibility allowed living cells to adhere and resulted in a short diffusion distance between H 2 O 2 released from cells and electrode.