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Voltammetric Study of the Antihistamine Drug Bilastine: Anodic Characterization and Quantification Using a Reusable MWCNTs Modified Screen Printed Carbon Electrode
Author(s) -
Teixeira Jorge Ginja,
Oliveira João
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060494
Subject(s) - carbon nanotube , anode , electrode , materials science , linear sweep voltammetry , antihistamine , cyclic voltammetry , detection limit , nanotechnology , chromatography , chemistry , electrochemistry , medicine , pharmacology
Abstract The anodic behaviour and the electroanalytical quantification of the second‐generation antihistamine bilastine (BIL) were investigated for the first time. A multi‐walled carbon nanotubes (MWCNTs) film‐coated screen printed carbon electrode (SPCE), as well as cyclic (CV) and linear sweep (LSV) voltammetry, were used for that purpose. The results showed that BIL undergoes an irreversible two‐electron oxidation process at the MWCNTs‐SPCE sensor. It was also found that the sensor can be reused after a simple and rapid reconditioning procedure. The proposed method was applied to the quantification of BIL in pharmaceutical formulations and spiked urine samples, and good recoveries were obtained.