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Application of MWCNT/Ag‐Pt Nanocomposite Modified GCE for the Detection of Nevirapine in Pharmaceutical Formulation and Biological Samples
Author(s) -
Okumu Fredrick O.,
Silwana Bongiwe,
Matoetoe Mangaka C.
Publication year - 2020
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060374
Subject(s) - differential pulse voltammetry , detection limit , carbon nanotube , cyclic voltammetry , dielectric spectroscopy , nanosensor , nevirapine , reproducibility , materials science , nanocomposite , voltammetry , nuclear chemistry , electrochemistry , chemistry , chromatography , electrode , nanotechnology , human immunodeficiency virus (hiv) , medicine , family medicine , antiretroviral therapy , viral load
A study of nanosensor comprising of a glassy carbon electrode modified with a composite of multiwall carbon nanotube (MWCNT) and bimetallic (Ag‐PtNPs) for the determination of Nevirapine. The GCE/MWCNT/Ag‐PtNPs sensor had remarkable electrocatalytic properties with enhanced response towards Nevirapine under optimized conditions. The platform electrochemical characterisation in 0.01 M NaOH solution, with cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) is detailed. The limit of the detection (LOD) was 0.021 μM. The nanosensor was validated for real sample study using spiked pharmaceutical dose form, milk and urine samples, which showed acceptable recoveries (90‐ 112 %), good precision (RSD=3.3 %, N=3), reproducibility (RSD=4.3 %) and excellent selectivity towards Nevirapine from studied interferents.