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Sensitive Determination of 17β‐Estradiol using a Magneto Sensor Based on Magnetic Molecularly Imprinted Polymer
Author(s) -
Nunes da Silva Daniela,
Leijoto de Oliveira Hanna,
Borges Keyller Bastos,
Pereira Arnaldo César
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060223
Subject(s) - molecularly imprinted polymer , adsorption , differential pulse voltammetry , selectivity , chemistry , carbon paste electrode , analyte , electrode , detection limit , molecular imprinting , chromatography , cyclic voltammetry , analytical chemistry (journal) , materials science , electrochemistry , organic chemistry , catalysis
The analysis of 17β‐estradiol with high sensitivity and selectivity is extremely relevant to control the impacts that this compound can cause on health and the environment. Thus, we describe the development and application of a magneto carbon paste electrode based on magnetic molecularly imprinted polymer (MCPE‐MMIP) for determination of 17β‐estradiol. The analyte adsorbed on the MMIP was immobilized on the electrode surface by magnetic capture. The morphological and structural characterization of the obtained MMIP suggests that the material was effectively synthesized. MCPE‐MMIP showed an improvement in the sensitivity for 17β‐estradiol detection when compared to electrode configurations in the absence of this material. The optimum conditions (0.10 mol L −1 phosphate buffer pH 7.0) were reached by differential pulse adsorptive stripping voltammetry (DPAdSV), in which the method presented linearity ranged from 0.06 to 175 μmol L −1 with limits of detection and quantification of 0.02 and 0.06 μmol L −1 , respectively. The proposed sensor was applied effectively in the analysis of 17β‐estradiol in river water and raw milk samples, exhibiting excellent recovery values (between 96.20 and 104 %), which were confirmed by HPLC analysis.