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Electrochemical Study of Different Sensors for Simple and fast Quantification of Ciprofloxacin in Pharmaceutical Formulations and Bovine Milk
Author(s) -
Faria Lucas Vinícius,
Lisboa Thalles Pedrosa,
Alves Guilherme Figueira,
Farias Davi Marques,
Matos Maria Auxiliadora Costa,
Muñoz Rodrigo Alejandro Abarza,
Matos Renato Camargo
Publication year - 2020
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060211
Subject(s) - detection limit , amperometry , chromatography , linear range , ciprofloxacin , graphene , materials science , dilution , electrolyte , chemistry , electrode , electrochemistry , analytical chemistry (journal) , nanotechnology , biochemistry , physics , thermodynamics , antibiotics
In this paper, bare glassy carbon electrode (GCE), multi‐walled carbon nanotubes (MWCNT/GCE) and reduced graphene oxide (RGO/GCE) were to verify the ciprofloxacin oxidation process. The RGO/GCE electrode provided a 9‐fold increase in the analytical signal and a potential displacement of 50 mV. A method using flow injection analysis with amperometric detection has been developed for simple and fast detection of ciprofloxacin in pharmaceutical formulations and bovine milk. The method presented adequate analytical characteristics, limit of detection (LOD<0.1 μmol L −1 ), simple sample treatment (only dilution supporting electrolyte), analytical frequency (110 analyzes per hour), satisfactory linear range (1–100 μmol L −1 ) and good precision (RSD<3%). The method was applied in six samples with satisfactory accuracy (recovery values in the range of 101 to 113 %). The ciprofloxacin contents were in agreement with the values provided by the drug labels, while the levels in the milk samples were below the LOD. The results obtained for both applications were statistically equivalent to the results obtained by liquid chromatography, at a 95 % confidence level.