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Facile Electrochemically Reduced Graphene Oxide‐Multi‐walled Carbon Nanotube Nanocomposite as Sensitive Probe for in‐vitro Determination of Nitrofurantoin in Biological Fluids
Author(s) -
Kummari Shekher,
Sunil Kumar V.,
Vengatajalabathy Gobi K.
Publication year - 2020
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060157
Subject(s) - carbon nanotube , materials science , graphene , nanocomposite , differential pulse voltammetry , detection limit , oxide , cyclic voltammetry , overpotential , nanosensor , nanotechnology , chemical engineering , electrode , electrochemistry , chemistry , chromatography , engineering , metallurgy
In this work, electrochemically reduced graphene oxide ‐ carbon nanotube (multi‐walled) nanocomposite modified glassy carbon electrode (ErGO‐CNT/GCE) has been investigated for direct electrochemical determination of nitrofurantoin (NFT), which is the prime drug used in the treatment of urinary tract infection. Surface of ErGO‐CNT/GCE has shown leafy flake‐like layers on the nanowire bed of CNTs, promising porous surface structure with enhanced surface area. ErGO‐CNT/GCE showed high peak current along with low overpotential in sensing NFT. In differential pulse voltammetry studies, the low detection limit is 20 nM. Steady state current ‐ time analyses carried out in buffer and serum samples resulted a low‐detection‐limit of 1.87 nM with the analysis time of mere 5 s. Practical application of the fabricated sensor for NFT determination in serum samples has been demonstrated.