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Titanium Dioxide/Multi‐walled Carbon Nanotubes Composite Modified Pencil Graphite Sensor for Sensitive Voltammetric Determination of Propranolol in Real Samples
Author(s) -
Dehnavi Azar,
Soleymanpour Ahmad
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060132
Subject(s) - materials science , dielectric spectroscopy , detection limit , electrode , cyclic voltammetry , electrochemical gas sensor , scanning electron microscope , analytical chemistry (journal) , fourier transform infrared spectroscopy , graphite , differential pulse voltammetry , electrochemistry , nuclear chemistry , chemical engineering , composite material , chemistry , chromatography , engineering
Abstract A very effective electrochemical sensor for the analysis of propranolol was constructed using TiO 2 /MWCNT film deposited on the pencil graphite electrode as modifier. The modified electrode represented excellent electrochemical properties such as fast response, high sensitivity and low detection limit. The proposed sensor showed an excellent selective response to propranolol in the presence of foreign species and other drugs. The electrochemical features of the modified electrode were investigated by cyclic voltammetry and electrochemical impedance spectroscopy (EIS) technique which indicated a decrease in resistance of the modified electrode versus bare PGE and MWCNT/PGE. The surface morphology for the modified electrode was determined by scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FT‐IR). Differential pulse technique (DPV) was used to determine propranolol which showed a good analytical response in the linear range of 8.5×10 −8 ‐6.5×10 −6 M with a limit of detection 2.1×10 −8 M. The TiO 2 /MWCNT/PGE sensor was conveniently applied for the measurement of propranolol in biological and pharmaceutical media.