Premium
Electroanalysis of Interleukins 1β, 6, and 12 in Biological Samples Using a Needle Stochastic Sensor Based on Nanodiamond Paste
Author(s) -
IlieMihai Ruxandra Maria,
Gheorghe Sorin Sebastian,
Stefanvan Staden RalucaIoana,
Bratei Alexandru
Publication year - 2021
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202060118
Subject(s) - nanodiamond , urine , interleukin , brain tissue , biomedical engineering , materials science , chemistry , medicine , biochemistry , cytokine , immunology , diamond , metallurgy
Interleukins proved to be valuable biomarkers for different diseases. Interleukins 1β, 6, and 12 can be used as biomarkers for brain cancer diagnosis, and therefore this paper proposed a needle stochastic sensor based on protoporphyrin IX immobilized in nanodiamond paste for fast screening of biological samples such as whole blood, urine and brain tumoral tissue for these interleukins. The results obtained using this needle stochastic sensor proved that the interleukins 1β, 6, and 12 can be reliable determined from whole blood, urine and brain tumoral tissue, with recoveries higher than 96.00 %, with relative standard deviations lower than 1.00 %.