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Design of a New Non‐enzymatic Sensor Based on a Substituted A 2 BO 4+δ Perovskite for the Voltammetric Detection of Glucose
Author(s) -
Boubezari Imane,
Zazoua Ali,
Bessueille François,
Errachid Abdelhamid,
JaffrezicRenault Nicole
Publication year - 2020
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202000062
Subject(s) - disproportionation , cyclic voltammetry , detection limit , calcination , monoclinic crystal system , materials science , electrode , electrochemistry , perovskite (structure) , catalysis , inorganic chemistry , nuclear chemistry , chemistry , crystal structure , crystallography , chromatography , organic chemistry
Instant determination of glucose levels is necessary to monitor the treatment of diabetes. The next generation of electrochemical sensors aims to eliminate the use of enzymes because of their lack of stability and the complex procedure to immobilize them on the electrode. In this paper Pr 1.92 Ba 0.08 Ni0. 95 Zn 0.05 O 4+δ perovskite, a A 2 BO 4+δ type, was tested, for the first time for non enzymatic detection of glucose. It was synthesized by a sol‐gel method. The obtained crystallized powder was structurally characterized by XRD, morphologically characterized by SEM and EDX and electrochemically characterized. A monoclinic crystallographic system was formed. The presence of Pr 2 O 3 during synthesis and calcination is in agreement with the formation of defects in the crystalline network and the disproportionation of Ni III sites into Ni II and Ni IV , due to the substitution of Pr by Ba. The oxido‐reduction of Ni II sites is observed by cyclic voltammetry. The electrocatalytic oxidation of glucose through the electrooxidized Ni II site was observed on a gold electrode, at 481 mV. The analytical performance of this glucose sensor is good in comparison to previously published ABO 3 perovskite modified electrodes, in terms of dynamic range (1.5 μM–7000 μM) and detection limit (0.5 μM). Its application to human serum shows that there is no interference for glucose detection.