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Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids
Author(s) -
Rizk Mohamed,
Attia Ali K.,
Mohamed Heba Y.,
Elshahed Mona S.
Publication year - 2020
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.202000007
Subject(s) - linagliptin , empagliflozin , detection limit , chemistry , chromatography , square wave , cyclic voltammetry , voltammetry , electrochemistry , nuclear chemistry , electrode , materials science , type 2 diabetes , medicine , diabetes mellitus , physics , quantum mechanics , voltage , endocrinology
A cobalt oxide nanoparticles (Co 3 O 4 NPs) and multi walled carbon nanotubes (MWCNTs) modified carbon paste electrodes were used to study the electrochemical behavior of linagliptin and empagliflozin in Britton Robinson buffer solution of pH 8.0 using cyclic and square wave voltammetry. The above mentioned modified electrodes showed highly sensitive sensing and gave an excellent anodic response for both drugs. The peak current varied linearly over the concentration ranges: 3.98×10 −5 –1.53×10 −3 mol L −1 (18.82–723.00 μg/mL) and 7.94×10 −6 –1.07×10 −4 mol L −1 (3.65–48.25 μg/mL) with determination coefficients of 0.9999 and 0.9998 for linagliptin and empagliflozin, respectively. The recoveries and relative standard deviations were found in the following ranges: 98.80 %–102.00 % and 0.23 %–1.90 % for linagliptin and 98.30 %–101.80 % and 0.11 %–1.86 % for empagliflozin. The detection and quantification limits were 1.13×10 −5 and 3.76×10 −5 mol L −1 (5.34and17.77 μg/mL) for linagliptin, 1.71×10 −6 and 5.68×10 −6 mol L −1 (0.77 and 2.56 μg/mL) for empagliflozin. The proposed sensors have been successfully applied for the determination of the drugs in bulk, pharmaceutical formulations and biological fluids.