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Electrochemical Properties of Multilayered Coatings Implementing Thiacalix[4]arenes with Oligolactic Fragments and DNA
Author(s) -
Kuzin Yu. I.,
Gorbatchuk V. V.,
Rogov A. M.,
Stoikov I. I.,
Evtugyn G. A.
Publication year - 2020
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201900499
Subject(s) - electrochemistry , polyelectrolyte , cyclic voltammetry , ferricyanide , dielectric spectroscopy , coating , materials science , chemical engineering , molecule , layer (electronics) , glassy carbon , electrode , inorganic chemistry , nanotechnology , chemistry , organic chemistry , polymer , composite material , engineering
Layer‐by‐layer assembling of polyelectrolyte complexes on glassy carbon electrode utilizing derivatives of p‐tert‐ butylthiacalix[4]arene modified with oligolactic acid in cone , partial cone and 1,3‐alternate configurations has been performed and characterized by atomic force microscopy, electrochemical impedance spectroscopy and cyclic voltammetry. Structure, surface morphology and permeability of the coatings depended on the number and nature of individual layers. Configuration of macrocyclic core influenced the charge distribution and flexibility of polyelectrolytes and the electrochemical properties of the coatings. Partial substitution of oligolactic derivatives with the DNA molecules allowed distinguishing native, thermally and oxidatively damaged DNA by ferricyanide ion signals. The relationships between the coating structure and the content can be further used for development of electrochemical sensors devoted to the detection of specific DNA interactions.