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Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen
Author(s) -
Pham Tien Song Hiep,
Mahon Peter J.,
Lai Guosong,
Fu Li,
Lin ChengTe,
Yu Aimin
Publication year - 2019
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201900138
Subject(s) - graphene , materials science , oxide , electrochemistry , electrode , platinum , electrochemical gas sensor , detection limit , nanotechnology , reproducibility , selectivity , chemical engineering , linear range , chemistry , chromatography , catalysis , organic chemistry , metallurgy , engineering
Over the past years, the development of electrochemical sensing platforms for the sensitive detection of drug molecules have received great interests. In this research study, we introduced cauliflower‐like platinum particles decorated reduced graphene oxide modified glassy carbon electrode (Pt−RGO/GCE) as an electrochemical sensing platform for highly sensitive determination of acetaminophen (ACTM). The sensor was prepared via a simple and environmentally friendly two‐step electrodeposition method at room temperature. The combination of conductive RGO nanosheets and unique structured Pt particles (average 232 nm in diameter) provided an efficient interface with large effective surface area which greatly facilitated the electron transfer of ACTM. The experimental conditions that might affect the drug detection were studied in detail and optimized for best performance. The Pt−RGO/GCE was able to detect ACTM up to the limit of 2.2 nM with a linear concentration range from 0.01 to 350 μM. With its high reproducibility, excellent stability and selectivity, the as‐fabricated sensor was successfully applied to the ACTM content measurement in commercial tablets.