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Inside Cover: Butylacrylate‐nucleobase Conjugates as Targets for Two‐step Redox Labeling of DNA with an Osmium Tetroxide Complex (Electroanalysis 2/2018)
Author(s) -
HavranováVidláková Pavlína,
Špaček Jan,
Vítová Lada,
Hermanová Monika,
Dadová Jitka,
Raindlová Veronika,
Hocek Michal,
Fojta Miroslav,
Havran Luděk
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201880202
Subject(s) - nucleobase , chemistry , osmium , dna , osmium tetroxide , redox , combinatorial chemistry , adduct , conjugate , chemical modification , bipyridine , photochemistry , stereochemistry , polymer chemistry , organic chemistry , ruthenium , biochemistry , mathematical analysis , electron microscope , physics , mathematics , crystal structure , optics , catalysis
The cover picture shows an illustration of a two‐step DNA modification with the electroactive OsO 4 2,2’‐bipyridine complex (Os,bpy), consisting in enzymatic construction of DNA bearing butyl acrylate (BA) moieties attached to U or to 7‐deaza A, followed by chemical modification of a reactive C=C double bond in the BA residue. We demonstrate modification of the BA conjugates not only in single‐stranded, but also in double‐stranded (ds) DNA in which modification within the nucleobase rings in is hindered. Various DNA‐Os,bpy adducts can be analyzed electrochemically and distinguished by its redox potentials. For the details see the article by P. Havranová‐Vidláková et al. DOI: 10.1002/elan.201700702