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Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine
Author(s) -
Tomé Luciana I. N.,
Brett Christopher M. A.
Publication year - 2019
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800816
Subject(s) - detection limit , differential pulse voltammetry , polymer , electrochemistry , electrode , materials science , cyclic voltammetry , nanoparticle , glassy carbon , electrolyte , nuclear chemistry , chemistry , chromatography , nanotechnology , composite material
Novel electrochemical sensors for epinephrine (EP) based on a glassy carbon electrode (GCE) modified with a redox polymer film and iron (III) oxide nanoparticles (Fe 2 O 3 NP) have been developed. Two redox polymers‐poly(brilliant cresyl blue) (PBCB) and poly(Nile blue) (PNB), and two different architectures‐polymer/Fe 2 O 3 /GCE and Fe 2 O 3 /polymer/GCE were investigated. The electrochemical oxidation of epinephrine at the modified electrodes was performed by differential pulse voltammetry (DPV), in pH 7 electrolyte, and the analytical parameters were determined. The results show enhanced performance, more sensitive responses and lower detection limits at the modified electrodes, compared to other electrochemical epinephrine sensors reported in the literature. The best voltammetric response with the lowest detection limit was obtained for the determination of epinephrine at PBCB/Fe 2 O 3 /GCE. The novel sensors are reusable, with good reproducibility and stability, and were successfully applied to the determination of epinephrine in commercial injectable adrenaline samples.