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Electrochemical Sensor Based on Multi‐walled Carbon Nanotubes and Cobalt Phthalocyanine Composite for Pyridoxine Determination
Author(s) -
Porto Laís Sales,
da Silva Daniela Nunes,
Silva Maria Cristina,
Pereira Arnaldo César
Publication year - 2019
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800789
Subject(s) - detection limit , pyrolytic carbon , pyridoxine , electrochemical gas sensor , differential pulse voltammetry , electrochemistry , carbon nanotube , materials science , carbon paste electrode , voltammetry , linear range , charge transfer coefficient , phthalocyanine , cyclic voltammetry , chemistry , nuclear chemistry , electrode , analytical chemistry (journal) , chromatography , nanotechnology , organic chemistry , biochemistry , pyrolysis
In this work, an electrochemical sensor based on pyrolytic graphite electrode (PGE), cobalt phthalocyanine (CoPc) and multiwalled carbon nanotube (MWCNT) composite designed as PGE‐MWCNT/CoPc was developed and validated for pyridoxine (vitamin B6) determination employing Differential Pulse Voltammetry (DPV). The electrochemical behaviour of pyridoxine at the PGE‐MWCNT/CoPc has been evaluated and the charge transfer coefficient, α, and the charge transfer rate constant, κ, were calculated as 0.30 and 11.67±0.43 s −1 , respectively, which indicates that, although this system is irreversible, it is viable kinetically to be used as a sensor. The optimized experimental conditions were pH 5.5 in 0.30 mol L −1 phosphate buffer. The linear range found was 10 to 400 μmol L −1 of pyridoxine, with r=0.9987. The limits of detection and quantification were 0.50 and 1.67 μmol L −1 , respectively, showing the good sensitivity of the method. The method was successfully applied for the pyridoxine determination in real samples of pharmaceutical formulation with RSD% lower than 5 % indicating that it can be used for routine quality control pharmaceutical formulations containing pyridoxine. Furthermore, it has the advantages of a fast response, a low detection limit and low cost.