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Preparation of a Double‐step Modified Carbon Paste Electrode for Trace Quantification of Acyclovir Using TiO 2 Nanoparticle and β‐Cyclodextrin
Author(s) -
KarimNezhad Ghasem,
Khorablou Zeynab,
Mehdikhani Shabnam
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800566
Subject(s) - electrode , materials science , detection limit , differential pulse voltammetry , cyclic voltammetry , carbon paste electrode , electrochemistry , nanoparticle , composite number , analytical chemistry (journal) , scanning electron microscope , chemical engineering , nanotechnology , nuclear chemistry , composite material , chemistry , chromatography , engineering
In this work we reported, a simple and reproducible double‐step modified carbon paste electrode (CPE) for recognition and designation of Acyclovir (ACV). In the first stage, for acquiring the structure of TiO 2 NPs‐CPE, 5 % TiO 2 nanoparticles (NPs) doped into the electrode tissue. In the second stage, β‐Cyclodextrin (β‐CD) anchored on the TiO 2 NPs‐CPE surface by electropolymerization which yields a β‐CD/TiO 2 NPs‐CPE. Topography, characteristics and electrochemical response of the fabricated electrodes with such techniques as: the field emission scanning electron microscopy (FESEM), chronocoulometry (CC), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were analyzed. Also the spent TiO 2 NPs powders were characterized by X‐ray diffraction (XRD). The results illustrated that this sensor designed efficiently increases the surface area of composite electrode and the performance of the oxidation of ACV at the surface modified electrode compared to the bare electrode improved. Under the desirable situations, the proposed of analytical procedure was proved to be applicable in two linear calibration ranges betwixt 0.09 to 2.98 and 2.98 to 47.61 μM. The detection limit was estimated for low concentrations ACV 21 nM (S/N=3). Eventually, the fabricated composite electrode was successfully applied for the detection of trace amounts of the ACV in the blood serum samples.