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Morphine Sensing by a Green Modified Molecularly Imprinted Poly L‐Lysine/Sodium Alginate‐activated Carbon/Glassy Carbon Electrode Based on Computational Design
Author(s) -
Salajegheh Maryam,
Kazemipour Maryam,
Foroghi Mohammad Mehdi,
Ansari Mehdi
Publication year - 2019
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800395
Subject(s) - detection limit , electrode , molecularly imprinted polymer , morphine , electrochemistry , materials science , composite number , central composite design , electrochemical gas sensor , carbon fibers , chemical engineering , chromatography , response surface methodology , chemistry , selectivity , composite material , catalysis , organic chemistry , medicine , engineering , pharmacology
A different molecularly imprinted composite film with the exploit of computational design is synthesized. The proposed composite is used for electrode modification to determine morphine. The ratio of monomer to template in optimum condition was obtained 4. The modification of the electrode was achieved by electropolymerizing L‐lysine in the presence of morphine on the surface of sodium alginate and activated carbon (SA‐AC) on glassy carbon electrode (GCE). The SA‐AC composite with special surface area suits for making sensitive sensors. Morphine showed an anodic peak in buffer solution of phosphate (pH=6.0) on MIP/SA‐AC/GCE. The optimization of the practical factors on the response and electrochemical behavior of template morphine on the modified electrode were precisely surveyed. The DPV outcomes exhibit high sensitivity for morphine detection within 0.1–1000.0 μM and limit of detection as 48 nM (S/N=3). The application of this disposable sensor in the case of urine samples was quite satisfactory.