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A Glucose Selective Non‐enzymatic Potentiometric Chitosan‐Goldnanoparticle Nanocomposite Sensor Based on Boronic Acid‐Diol Recognition
Author(s) -
Çelik Filiz,
Çiftçi Hakan,
Tamer Uğur
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800372
Subject(s) - boronic acid , chitosan , potentiometric titration , colloidal gold , detection limit , biosensor , potentiometric sensor , linear range , nanoparticle , chemistry , nuclear chemistry , electrode , chromatography , combinatorial chemistry , materials science , nanotechnology , organic chemistry , biochemistry
Abstract A new non‐enzymatic glucose sensor based gold nanoparticle (AuNp)‐chitosan (Ch/AuNp) was developed in this study. Gold nanoparticles were synthesized by using the green synthesis method, in which chitosan is used as both reducing and stabilizing agent. Gold nanoparticle surfaces were modified with different molecular agents (4‐mercaptophenyl boronic acid,MPB, and 1‐decanethiol,DT) being sensitive to glucose. Modified gold nanoparticles were immobilized to electrode surfaces and used for the glucose measurements by the potentiometric method. The best working conditions were determined for the glucose measurements. It was found that linear working range is 0.5–30 mM, while limit of detection is 0.3 mM for the glucose measurement of the prepared non‐enzymatic sensor. It was stated that the prepared sensor could be used at least 6 times and glucose response decreased approximately 10.97 % when it is waited for 30 days. Interference effect of some molecules for glucose measurement was investigated and usability of developed sensor was tested in human blood serum.