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Development of Electrochemical Sensor Based on Glassy Carbon Electrode Modified with a Molecularly Imprinted Copolymer and its Application for Detection of Repaglinide
Author(s) -
Roushani Mahmoud,
Jalilian Zeynab
Publication year - 2018
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201800322
Subject(s) - detection limit , molecularly imprinted polymer , selectivity , electrochemical gas sensor , copolymer , materials science , electrode , linear range , electrochemistry , monomer , carbon paste electrode , glassy carbon , molecular imprinting , chemical engineering , polymer , chemistry , chromatography , organic chemistry , catalysis , cyclic voltammetry , composite material , engineering
At the present study, we have reported a new sensor based on immobilized molecularly imprinted polymer on the surface of a glassy carbon electrode (GCE) through electro polymerization of o‐Dihydroxybenzene (o‐DB) and o‐phenylenediamine (o‐PD) as monomers for direct determination of repaglinide (RPG) as target molecule. RPG is a new generation of oral anti‐diabetic drugs that has a rapid onset of action and short half‐life of approximately 1 h. So developing a controlled system with good sensitivity and selectivity is required to eliminate its adverse effects. Under the optimized conditions, the proposed sensor showed a good selectivity to detect RPG among compounds with similar structure and properties with RPG. The linear range for analysis were 0.005–1.0 μM and detection limit 1.8 nM was achieved. Furthermore, the experimental results showed that the proposed sensor was highly selective and sensitive to detect RPG in real samples such as blood serum, urine and RPG tablet.